<原著>虚血・再灌流心の心機能と心筋代謝に対するAcetylsalicylic Acidの心筋保護効果
スポンサーリンク
概要
- 論文の詳細を見る
The effect of acetylsalicylic acid (ASA) on high energy phosphates (adenosine triphosphate : ATP, creatine phosphate : CrP, inorganic phosphate : Pi) and intracellular pH during myocardial ischemia and reperfusion was studied with phosphorus 31-nuclear magnetic resonance (^<31>P-NMR) in the isolated rabbit hearts. Also, coronary flow and left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and left ventricular systolic developed pressure (LV Dev. P) were measured. Langendorff hearts perfused at 37℃with perfluorochemical emulsion Fluosol-43 were subjected to 15 min and 30 min zero-flow ischemia and 15 min low-flow ischemia (coronary perfusion pressure=20 mmHg), following by 65 min of reperfusion (Group I). ASA (0.28 mM) was infused for the entire experimental period from 45 min prior to ischemia (Group II) and infused immediately after reperfusion (Group III). During ischemia, Group II showed a significant suppression of the decrease in ATP level and pH in both zero-flow and low-flow ischemia compared to that in other groups, moreover the increase of Pi and the decrease of CrP in low-flow ischemia was suppressed. In Group III, ATP level during reperfusion was significantly higher than Group I, but not significantly different from that in 30 min zero-flow ischemia. In 30 min zero-flow ischemia, Pi, CrP and coronary flow after reperfusion in Group II tended to recover to preischemic values. There were no differences in LV Dev. P among the 3 groups. In conclusion, ASA has a protective effect on myocardial high energy phosphates during ischemia and reperfusion in rabbit hearts.
- 近畿大学の論文
- 1994-03-25
著者
関連論文
- Stunned Myocardiumに対するAcetylsalicylic Acid前投与及び後投与の効果 : 兎灌流心での検討 : 日本循環器学会第73回近畿地方会
- 虚血・再灌流心の心機能と心筋代謝に対するAcetylsalicylic Acidの心筋保護効果
- 閉胸下ゲラチンスポンジ塞栓による犬心筋梗塞の組織学的特徴 : 日本循環器学会第72回近畿地方会
- 4.肺動脈楔入圧上昇を伴わず著明な肺うっ血像を呈し発症20日目に心破裂死した後下壁心筋梗塞の1例
- 13.拘束型心筋症が疑われた1症例