<原著>コラーゲン関節炎マウスおよび慢性関節リウマチ患者の骨髄細胞におけるヒスタミンH_2受容体機能

概要

論文の詳細を見る
We demonstrated the presence of histamine H_2-receptors in the bone marrow cells in mice and humans by production of cyclic AMP (cAMP). The production of cAMP induced by histamine and H_2 receptor agonists was significantly reduced in the bone marrow cells of the collagen-induced arthritis mice (CIA) and the patients with rheumatoid arthritis (RA). These findings indicated a hypofunction of histamine H_2-receptors in the bone marrow cells both in CIA mice and RA patients. We examined the effects of histamine receptors on interleukin 6 (IL-6) production in the human bone marrow cells. Both histamine and H_2 receptor agonists significantly reduced the production of IL-6 in the bone marrow cells from patients with osteoarthritis (OA) (used as control subjects). On the other band, the H_1-receptor agonist had no significant effects on IL-6 production in the bone marrow cells. These findings indicated that histamine suppressed IL-6 production in the bone marrow cells through the H_2-receptor. In the bone marrow cells with RA patients, these inhibitory effects of histamine and H_2-receptor agonists on IL-6 production were significantly decreased. These findings suggested the involvement of hypofunction of histamine and H_2-receptors in the bone marrow cells in the perpetuating inflammatory process in CIA and RA.
近畿大学の論文
1991-12-25