<原著>気管支喘息患者多核白血球の気管支上皮細胞傷害性について : とくにComplement Receptor Type 3の関与について

概要

論文の詳細を見る
Inflammation in the airway, which is caused by inflammatory cells including eosinophils and neutrophils, is related with the late asthmatic response and persistent airway hyperreactivity. The characteristics of polymorphonuclear leukocytes (PMN)-mediated natural cytotoxicity against bronchial epithelial cell line (AK-D) in bronchial asthma were investigated. PMN-mediated natural cytotoxicity in bronchial asthma was significantly greater than in normal subjects. The cytotoxicity was enhanced by stimulation of CR3 with the monoclonal anti-CR3 antibody of both patients with bronchial asthma and normal subjects. However, no enhancement with CR3 stimulation was observed in asthma attack patients. Moreover, when optimal doses of the monoclonal anti-CR3 antibody were used, no differences in CR3 expression were observed among these groups. However, when suboptimal doses were used, CR3 expression in patients with bronchial asthma during attack was weaker than in the normal subjects or the patients with asthma not during attack.
近畿大学の論文
1991-06-25