<原著>ヒト培養滑膜細胞におけるヒスタミンの役割

概要

論文の詳細を見る
We demonstrated the presence of histamine H_1 and H_2 receptors on the synovial fidroblast using binding studies. Histamine enhanced synovial proliferation and stimulated the release of hyaluronic acid from the synovial fibroblast through the H_1 and H_2 receptors. The molecular weight of hyaluronic acid decreased upon the stimulation by histamine. This indicated that the synovial fibroblasts from rheumatoid arthritis had imperfect functions on the H_2 receptor. These findings indicate that histamine modulates the release of hyaluronic acid and that the synovitis of rheumatoid arthritis is a specific state according to the dysfunction of the histamine H_2 receptor.
近畿大学の論文
1991-03-25