<原著>ラット関節滑膜におけるコリン作動性神経

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概要

• 論文の詳細を見る

• Uptake of [^3H] choline and release of [^3H] acetylcholine (ACh) were examined in the synovial membrane of the rat knee joint. Kinetic analysis of [^3H] choline uptake revealed two uptake systems, a high affinity component with a Km of 3.1×10^<-6>M and a low affinity one with a Km of 66×10^<-6>M. [^3H] Choline uptake was inhibited by removal of external Na^+ or treatment with hemicholinium-3. High K^+ evoked release of [^3H] ACh from the membrane preloaded with [^3H] choline was Ca^<2+>-dependent and Mg^<2+>-sensitive. γ-Aminobutyric acid (GABA) and GABA_A receptor agonist (muscimol) evoked [^3H] ACh releases were inhibited by bicuculline. High K^+ evoked [^3H] ACh release was inhibited by GABA_B receptor agonist (baclofen). These results suggest the existences of cholinergic neurons and GABA receptor in the rat synovial membranes, and interaction of the two.

• 近畿大学の論文
• 1990-03-25

著者

• 久保田 恭

  近畿大学医学部整形外科学教室

関連論文

• 5.ラット頚部脊髄におけるGABA神経の免疫組織学的局在
• 7.ラット関節滑膜における^3H-choline uptake
• 5.ラット関節滑膜におけるGABAの存在
• ラット関節滑膜におけるコリン作動性神経

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