<原著>癌の転移形成過程の解析 : 自然肺転移形成株と非形成株の接着能の比較

概要

論文の詳細を見る
Using two human lung adenocarcinoma cell lines KUM・LK-2,a strain having spontaneous metastasis-forming capacity, and HLC-1,a strain without such capacity, the adhesive property of cancer cells was investigated with references to the interrelation between vascular endothelial cells and platelets as well as damages of vascular endothelial cells. The adhesive property of HLC-1 for vascular endothelial cells was significantly higher than that in KUM・LK-2,whereas KUM・LK-2 showed greater cell adhesion to Type IV collagen and extracellular substrate. In the presence of platelets, the adhesive property for vascular endothelial cells was enhanced only in KUM・LK-2. Thus, cancer cells that can aggregate platelets, impair platelet aggregating activity, damage vascular endothelial cells, and have a strong affinity for the extracellular substrate appeared to associated with metastasis.
近畿大学の論文
1990-03-25