<原著>IgA腎炎における補体による糸球体障害の免疫組織学的研究
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the mechanism of glomerular injury in IgA nephropathy, renal biopsy specimens taken from 50 patients with IgA nephropathy were examined by immunohistochemical stainings and electron microscopy. The glomerular localization of immunoglobulins (IgA and IgG), complement components (C4,C3,C5 and C9), and terminal complement complex (C5b-9) were analyzed by immunoelectron micrscopy. The association between C5b-9 deposition and striated membranous structure (SMS) was also studied. Immunofluorescent staining for C5b-9,along with IgA, IgG and C3,was frequently positive in the mesangium of the patients. Glomerular adhesion to Bowman's capsule and proteinuria were more prominent in patients with marked C5b-9 deposition in the glomeruli. Immunoelectron microscopic studies showed that IgA was predominantly localized beneath the basement membrane of mesangial area, and that IgG was also present in the same area. Deposits stained for C3,C5,C9 and C5b-9 were found in mesangial area and glomerular capillary walls, but C4 deposition was less frequent. Various staining patterns for immunoglobulins and complement components were observed in electron dense deposits (EDD). C5b-9 deposition was frequently found in SMS. The C5b-9 in subepithelial SMS was significantly correlated with severity of mesangial proliferation. These results suggest that the terminal complement activation in glomeruli in situ is frequently associated with EDD and SMS plays an important role in glomerular injury in IgA nephropathy.
- 近畿大学の論文
- 1990-03-25
著者
関連論文
- IgA腎炎における補体による糸球体障害の免疫組織学的研究
- 6.腎組織におけるマクロファージ, T, B cellの同定とその意義
- 10.Dense deposit diseaseの1例
- 16.紫斑病性腎炎とIgA腎症における螢光抗体法による観察
- 21.溶血性尿毒症性症候群の2例
- 32.小児IgA腎症の臨床病理学的検討
- 14.Membranous nephropathy with mesangial proliferationの1例
- 顔面の腫脹により発見された好酸球性肉芽腫症の1症例 (腫瘍)