<原著>ウサギ肝臓の細胞内K^+に及ぼすCO_2の影響について
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概要
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Membrane potential (E_M) and intracellular K^+ activity (aKi) of rabbit liver cells were measured in vivo with double-barrelled K^+-selective microelectrodes. Moreover, the plasma K^+ concentrations, as well as E_M and aKi of the liver cells, were measured in rabbits under 25% CO_2 loading. In the normal control animals, E_M was distributed around a mean of -52.2±7.4mV (SD), over the range from -37.5 to -75mV and aKi was distributed around a mean of 100.4±21.3mM(SD), over the range from 58.8 to 153.6mM. In the CO_2-loaded animals, E_M was depolarized from -55.2 to -37mV, aKi was decreased from 108 to 67.9mM, and plasma K^+ was increased from 2.7 to 3.0 mEq/l. These changes were reversible and recovered soon after the cessation of CO_2 loading. In conclusion, the effects of CO_2 would mainly be affected by 1) the leak of cell K^+ to the medium, and 2) the suppression of the Na^+-K^+ pump. Additional factors, such as the shift of water from the interstitium into the cell, which causes a cell swelling and the buffering capacity in the liver smaller than the other tissues might also contribute to the overall changes in the cell K^+ concentration of the liver.
- 近畿大学の論文
- 1989-03-25