ウサギおよびラット摘出血管におよぼすNeuromedin-Lの作用(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
The effects of neuromedin-L (new neuropeptide, NM-L), which was recently identified from human brain stem, on the isolated ring segments of basilar and mesenteric arteries in rabbits and rats (WKY and SHRSP) have been investigated in comparison with that of substance P. NM-L evoked vasodilatation to the arteries from both animals in a dose-dependent manner. The vasodilator effect of NM-L was weaker than that of substance P in rabbits, but was stronger in SHRSP than in WKY. On the other hand, in rats substance P did only relax slightly to both arteries. The vasodilator effect of NM-L was reduced by [D-Pro^2,D-Trp^<7,9>]-substance P (specific substance P antagonist). These results suggest that the vasodilator effect of NM-L exists in both species and regional difference, and is elicited in response to substance P receptor. The sensitive effect of NM-L on mesenteric arteries in SHRSP remains to be determined.
近畿大学の論文
1984-12-25