<原著>New Zealand blackマウスに対する正常マウス胸腺上皮細胞移植の影響

概要

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Thymus abnormality has been pointed out up to date in the New Zealand black (NZB) mouse which is a model of autoimmune disease. For the purpose of correcting the immunological abnormalities of the NZB mouse, cultured thymic reticuloepithelial cells (TRCs) of the normal BALB/c mouse whose major histocompatibility complex is compatible with that of the NZB mouse were transplanted into NZB mice every month from 2 weeks of age. Then, in three groups of the NZB mice which underwent no transplantation, fibroblast transplantation and TRC transplantation, respectively urinary protein, hematocrit, direct Coombs test, total spleen cell counts, Thy 1.2,Ly 1.2 and Ly 2.2 positive cells of the spleen, Con A and PHA response, IL-1 and IL-2 activity, anti-nuclear antibody and anti-DNA antibody were investigated. As a result, total spleen cell counts, Thy 1.2,Ly 1.2 and Ly 2.2 positive cells of the spleen, IL-1 activity and anti-DNA antibody were not changed by TRC transplantation. Improvements, however, were seen in urinary protein, hematocrit, direct Coombs test, Con A and PHA response, IL-2 activity and anti-nuclear antibody. These results suggest that transplantation with the TRC of normal mice to NZB mice might correct the immunological abnormalities and further the clinical parameters of autoimmune disease.
近畿大学の論文
1988-12-25