<原著>慢性関節リウマチおよび実験的関節炎におけるリンパ球, 滑膜のアドレナリン受容体

概要

論文の詳細を見る
Adrenergic receptor characteristics and adenylate cyclase responses were measured in the lymphocytes and synovial membranes of rheumatoid arthritis (RA) and experimental arthritis. The number of receptors for [^3H] dihydroalprenolol (DHA) and the cyclic adenosine monophosphate (cAMP) accumulation by isoproterenol were significantly reduced in the lymphocytes of RA and experimental arthritis compared with the normal controls. Such reduction was recovered with the remission of arthritis. Human T and B cells derived from RA showed the same reduction in beta-adrenergic function as the lymphocytes. Further the dissociation constant for [^3H]-WB4101 was significantly reduced in the synovial membranes of RA and experimental arthritis. For [^3H] DHA binding, a significant increase in the dissociation constant in experimental arthritis and a significant decrease in the number of receptor in RA were observed. These data suggest that the adrenergic receptor function plays a role in the activity of the arthritis.
近畿大学の論文
1988-06-25