<原著>実験的ネフローゼ症候群における各種サイコサポニンの尿蛋白排泄抑制作用 : 特に構造・活性相関について
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概要
- 論文の詳細を見る
The effects of the saikosaponins (a, b_1,b_2,c, d) extracted from the roots of Bupleurum falcatum L. on aminonucleoside (AN) induced nephrosis were examined and the mechanism was also studied. The rats used were given daily intraperitoneal injections of AN for 6 days and then treated with saline or 1.0mg/kg of saikosaponin (SS) a, b_1,b_2,c or d from the 2nd day after the last injection of AN. In the rats given AN and saline urinary protein excretion started to increase 2 days after the last injection of AN, and the significant decrease of serum protein and the increase of cholesterol were also observed on the 13th day. On the other hand, the administration of SSa or d resulted in a significant decrease of total urinary protein but SSb_1,b_2 and c did not show a significant effect on the excretion of urinary protein. In the rats treated with SSa or d, the levels of serum protein and cholesterol were also improved, compared to the control rats treated with AN and saline. Further, electron microscopical examination of the glomeruli of rats treated with AN and saline revealed definite abnormalities of the epithelial cells, fusion of the foot processes and the presence of vacuoles : The extent and the severity of lesions of the epithelial cells were significantly less in the rats treated with SSa or d after injections of AN than in the controls treated with AN and saline. Moreover, the staining of glomerular basement membrane with ruthenium red revealed the effect of saikosaponin on the anionic charge. The number of anionic sites stained with ruthenium red was slightly increased in the rats received both AN and SSd than in the rats treated with AN and saline.
- 近畿大学の論文
- 1988-06-25