<原著>滑膜におけるガンマアミノ酪酸の存在とその役割

概要

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In rats and humans γ-aminobutyric acid (GABA) content in the synovial membrane of the knee joint was measured, and the uptake and release of GABA were studied. GABA content of the normal rat synovial membrane was 20.1 nmol/g tissue. On the other hand, ten days after the unilateral dissections of sciatic nerve, femoral nerve and both nerves, the GABA contents of the ipsilateral membrane were 13.8,14.6 and 7.8nmol/g tissue, respectively. But the GABA content in the synovial membrane of antigen induced arthritis rats was 33.53 nmol/g tissue. High K^+ evoked the Ca^<2+>-dependent release of [^3H]GABA from the synovial membranes of intact rats preloaded with [^3H]GABA, but did not from the membrane ipsilateral to the dissection of both sciatic and femoral nerves. The evoked release of [^3H]GABA was obtained in the synovial membrane preloaded with [^3H]GABA in the presence of β-alanine, but scarcely in the case of 2,4-L-diaminobutyric acid. In rheumatoid arthritis (RA), GABA level of the synovial membrane was higher than those in osteoarthritis (OA) and meniscus injury. And in RA, the level of [^3H]GABA efflux was higher than in OA. These findings indicate that GABAergic neuron may be present in the synovial membrane, although it cannot be excluded that GABA occurs in the tissue other than the neurons. Thus GABA level present in the synovial membrane may be involved in the cause of inflammation.
近畿大学の論文
1988-03-25