<原著>大腸癌のリンパ管侵襲と間質反応のリンパ節転移に及ぼす影響 : clearing法による研究

概要

論文の詳細を見る
The mode of lymphnode metastasis of colo-rectal cancer was studied by using a modified clearing method in 261 resected specimens and also the effects of lymphatic vessel invasion as a tumor response and lymphoid infiltration as a host response on the lymphnode metastasis or the prognosis were investigated. 21,790 lymphnodes (83.5 nodes per case) were examined by modified clearing method and more than 19.6 nodes per case by conventional method. The metastatic rate of colo-rectal cancer to the lymphnode was 57.5% (56.7% for colonic cancer and 59.0% for rectal cancer). A higher degree of lymphatic vessel invasion (ly) was associated with a higher metastatic rate and a higher grade of metastasis, and as 'the site of ly' (the deepest site of lymphatic vessel invasion at the intestinal wall) shifted more from sm (sub-mucosa) to ss・a_1 (sub-serosa or adventitia), the metastatic rate and the grade of metastasis became higher. Not only lymphatic vessel invasion but also 'the site of ly' as a tumor factor affected the metastases to lymphnodes and thus the prognosis. The metastatic rate was found to be lower in patients with a severe lymphoid infiltration, while it was found to be higher in patients with a mild lymphoid infiltration. Lymphoid infiltration as a host factor appeared to be inhibitory against the invasion of cancerous cells into lymphatic vessels, affecting the metastases to lymphnodes and thus the prognosis.
近畿大学の論文
1987-09-25