<原著>冠動脈閉塞後再灌流時の心筋収縮機能とそれに対するdiltiazemの影響

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概要

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• This experiment was designed to examine the effect of diltiazem on the regional myocardial contraction during reperfusion after brief coronary occlusion in dogs. Two pairs of the ultrasonic crystals were implanted in the epicardial and the subendocardial myocardium of the region supplied by the left anterior descending coronary artery (LAD) which underwent occlusion for 1,5 and 15 min under intravenous pentobarbital sodium anesthesia. After 0.2-0.3 mg/kg diltiazem was intravenously injected, the same experiment was performed. End-diastolic SL (SLed), SL on the beginning of ejection (SLej), and SL on the end of ejection (SLes) were calculated. % systolic shortenint (%SS), % systolic isovolumic shortening (%SIS), and % systolic ejection shortening (%SES) were defined as follows ; %SS=100・(SLed-SLes)/SLed, %SIS= 100・(SLed-SLej )/SLed, and %SES=100・(SLej-SLes )/SLej. In the control group, 1 min occlusion produced no remarkable change of myocardial shortening during reperfusion, but 5 min occlusion produced a significant decrease in %SIS (p<0.05), and 15 min occlusion demonstrated a significant decrease in %SS (p<0.01) and %ESP/SLes, indicating a significantly deteriorated myocardial contractility (p<0.05). On the contrary, in diltiazem group each intervention of 1,5 and 15 min occlusion showed no significant decrease in %SS, %SIS, and %ESP/SLes after reperfusion. Thus, it seems reasonable to conclude that diltiazem can protect the ischemic myocardium during coronary occlusion and reperfusion from afterload reduction and the direct effect on metabolism in the ischemic myocardium.

• 近畿大学の論文
• 1987-06-25

著者

• 岡山 彰宏

  近畿大学医学部第1内科学教室

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• 冠動脈閉塞後再灌流時の心筋収縮機能とそれに対するdiltiazemの影響

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