<原著>乳癌における局所リンパ動態に関する研究
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The lymphodynamics in regional area of the breast cancer were studied with the lymphoscintigram using ^<99m>T_c-Human serum albumin (HSA). ^<99m>T_c-HSA 3 mCi was injected into the mammary tissue at upper margin of the primary growth in the breast cancer group and at outer (Lateral injected group) and inner half of the breast (Medial injected group) and upper margin of the areola (Central injected group) in the control group. After injection, data were collected for 15 seconds/l frame and 28 minutes by using digital gamma camera GCA-90A. The type of lymphatic flow on the lymphoscintigram was classified into 2 types, diffusing and flowing type. Further the flowing type was classified into 3 subtypes, axillary, parasternal and axillo-parasternal type. In the control group drainaging lymphatic region related with the site of injection. For example, when injected at outer half of the breast, the lymphatic flow drained toward axillary lymphatic region and at the areola region, toward parasternal one and at inner half of the breast, toward parasternal one. In the breast cancer group, drainaging lymphatic region of flowing type related with the site of primary growth but of diffusing type didn't relate with the site. Drainaging lymphatic region of diffusing type was toward parasternal lymphatic region. As concerns lymph node metastases, lymph node metastatic rate at axillary lymphatic region in axillary type was 7/18 (38.9%) but in parasternal type, parasternal metastases were not recognized. It suggests that lymphatic flow didn't relate with lymph node metastases. The clearance (T1/2) of ^<99m>T_c-HSA at injected site was 72.4 minutes on the average in the control group while 42.0 minutes about a half in the breast cancer group.
- 近畿大学の論文
- 1986-12-25
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