アスピリンの腸管吸収促進剤の研究
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概要
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An investigation was made on the absorption of aspirin in the intestinal canal combining varius medicines in order to accelerate the absorptin of the drug. Taurin was found to be most effective, that is, the increase of absorption factor of aspirin administered at a hal off dose together with taurin was about 50% higher than when aspirin was given alone. Some increase was also seen in combination of glucuronic acid. Glucosamine, glycine, alanine and methionine had no influence on the absorption factor of aspirin. It was also found that benzensulfonic acid, sulfamine, sodium sulfite and sodium bisulfite do not affect or rather inhibit the absorption of aspirin in the intestinal canal. From the above results, it can be considered that the increase of absorption factor of aspirin seen in combination with taurin may not be due to amino group or sulfone gulfone group, but peculiar to taurin.
- 共立薬科大学の論文
- 1960-03-20
共立薬科大学 | 論文
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