2-Amino-4-butylmercaptomethylthiazole, 2-Amino-5-butylmercaptothiazole 及び Butylsulfonyl-誘導体の合成
スポンサーリンク
概要
- 論文の詳細を見る
Bromination of butylsulfonylaceton (I) in glacial acetic acid yielded a monobromo compound, mp. 119°(from alcohol), when the reaction mixture was allowed to stand for about 0.5∿1.0 hour after discoloration of bromine. No depression of the melting point was observed on admixture with 1-butylsulfonyl-3-bromopropanone (II), obtained by the dry hydrogen bromide decomposition of the diazoketone (VIII) formed from butylsulfonylacetic chloride (VII) and diazomethane. The oily substance fromed by the reduction of (II) with zinc in glacial acetic acid gives the same 2,4-dinitro-phenylhydrazone as that of mp. 140°of (I). Condenstion of (II) and thiourea gave 2-amino-4-butylsulfonylmethylthiazole (III). 1-Butylmercapto-3-chloro-2-propanone obtained from butylmercaptoacetic chloride (IX) through diazoketone (X) gave 2-amino-4-butylmercaptomethylthiazole (XII) by condensation with thiourea, and its acetate (XIII), mp. 85°, is different that of the isomer, mp. 96∿98°. Admixture of (IV), obtained by the oxidation of (XIII), with the acetate of (III) showed no depression, but the admixture with the isomer of the same melting point, mp. 138°, i. e. 2-acetamino-4-methyl-5-butylsulfonylthiazole, showed depression. Reaction of 2-amino-5-bromothiazole (XIV) and alkylmercaptane, under the same conditions as those in the case of 2-amino-4-methyl-5-bromothiazole, gave the objective 5-alkylmercapto (XVI) and 5-alkylsulfonyl (XVII) derivatives, but these could not be detected by the method from butylmercaptoacetaldehyde diethyl acetal.
- 共立薬科大学の論文
- 1956-12-30
共立薬科大学 | 論文
- プロテイン摂取とトレーニングの関係 (II) : 身体組成, 血液成分の分析から
- 雄性ラット肝Δ^4-5β-Reductase
- INAH による⊿^4-3-Oxosteroids の比色定量
- 「薬学生のための体験学習プログラム」の実践 : リハビリテーション・介護福祉を理解するために
- 便秘の実態と便秘薬服用の問題点 : 第 2 報