Pharmacological Reseaches on Progestin Action [II] : Effect of Progestins on Nncleic Acids and Others in the Ovariectomized Rat Uterus
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概要
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The effects of progesterone and synthetic progestins, i.e., retroprogesterone, megestrol acetate, ethynodiol diacetate, and 19-norethysterone, on uterine RNA, DNA, protein contents and others were studied in ovariectomized adult rats. Progesterone and retroprogesterone decreased the estrogen-induced effects on the uterus. Megestrol acetate and ethynodiol diacetate were proved to have the estrogenic activities themselves and also to enhance the increasing of the uterine phosphates-levels by estradiol. 19-Norethysterone was estrogenic, as well as androgenic-anabolic, therefore, the effects of this steroid on RNA/DNA ratio, protein concentration and uterine weights were varied from the subjects. No particular change was observed in DNA concentration by any treatment studied in adult rats. The relationships between changes of uterine phosphates and biological activities were discussed.
- 共立薬科大学の論文
- 1970-10-30