多環式キノン類の発癌スクリーニング
スポンサーリンク
概要
- 論文の詳細を見る
Together with 1.4-naphthoquinone, 9,10-phenanthrenequinone and 9,10-anthraquinone, para and ortho quinones of benz [a] anthracene and dibenz [a, h] anthracene (DBA) were screened for their carcinogenic activity by hypodermic injection and application methods. For each quinone, a group of 30 (male 15,female 15) mice was tested using DBA or 20-methylcoranthrene [MC] as the positive control. In addition to these experiments, two meso substituted (7-bromo and 7-nitro) benz [a] anthra-5,6-quinones were also investigated by using DBA and benz [a] anthra-5,6-quinone as the controls. A group of 50 male mice was tested for each compound and some histological observation followed. All quinone tested were found to be noncarcinogenic in spite of the powerful carcinogenic activity on mice of DBA and MC. Only the negative data were obtained, but were summarized in Tables and the results were discussed a little.
- 共立薬科大学の論文
- 1966-05-20