<ARTICLE>Effect of Food Restriction or Voluntary Exercise on the Development of Non-Insulin Dependent Diabetes Mellitus (NIDDM) in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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概要
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We investigated the effect of food restriction or voluntary exercise on the development of non-insulin dependent diabetes mellitus (NIDDM) in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and the effect of NIDDM on mitogen response of their splenic lymphocytes. OLETF rats were divided into the following groups at the age of 5 weeks; sedentary, voluntary exercised and food-restricted (70% of the food intake in sedentary rats). Although sedentary OLETF rats showed the higher levels of plasma glucose and serum insulin, both voluntary exercise and food restriction significantly suppressed the increases in plasma glucose and serum insulin. In addition, mitogen response of splenic lymphocytes in OLETF rats was well-maintaind as compare with those of non-diabetic rats (Long-Evans Tokushima Otsuka; LETO), voluntary exercised and food-restricted OLETF rats. However, glucose consumption by splenic lymphocytes following in vitro incubation for 72h was lower in OLETF rats than those of other three groups. In contrast, the expression of glucose transporter-1 (GLUT-1) in splenic lymphocytes was higher in sedentary OLETF rats compared to those of other three groups. Glucose consumption per GLUT-1 in splenic lymphocytes resulted in inducing a significant decrease in sedentary OLETF rats, which may predict the decrease of cellular immunity in OLETF rats. These results suggest that food restriction and voluntary exercise prevent the development of NIDDM and the decrease of cellular immunity in OLETF rats.
- 山口県立大学の論文
- 2001-03-25