<SESSION>TRITIUM METABOLSIM IN ANIMALS AND ESTIMATION OF THE ACUMULATED DOSE

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This paper describes the recent advances in our laboratory in the development of the metabolic model of tritium retention for the animal body and the estimation of the dose modification factor for the organically bound tritium (OBT). Tritium retention data have been accumulated for the mice used as a model animal. These data stimulated us to propose a modified three compartment model in which the organically bound tritium (OBT) is directly taken in by a OBT compartment. This model predicts the specific activity ratio in tissue (SAR) as a function of the ratio of OBT intake compared to the intake of the free water tritium (FWT) in the daily diet at equilibrated condition. In a parallel work, the dose modification factor (DMF) for the OBT was estimated for the DNA-bound tritium and the protein-bound tritium. The DMF for the DNA-bound tritium and that for the protein-bound tritium were between 2 and 6 and between 0.8 and 1.5,respectively varying among various organs.
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