Regulation of the Expression of Epidermal Growth Factor Receptor mRNA with Thyroid Hormone L-3,5,3'-Triiodothyronine in Rat Hepatoma Cells

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概要

• 論文の詳細を見る

• The expression of epidermal growth factor (EGF) receptor mRNA was examined using thyroid hormone L-3,5,3'-triiodothyronine (T3) by Northern blot analysis in rat hepatoma cells. The expression of full-length, but not truncated receptor mRNA was enhanced and destabilized with T3. These results suggest that T3 induces not only the expression of full-length EGF receptor mRNA but also accelerates their rate of turnover. The 3' terminal region of full-length EGF receptor mRNA may have a role in the destabilization of EGF receptor mRNA by T3, because truncated EGF receptor mRNA lacks only the 3' terminal region of full-length EGF receptor mRNA.

• 鳥取大学の論文

著者

• SATOH Yukio

  Department of Surgery, University of Tsukuba

• Satoh Yukio

  Department Of Biosignaling Faculty Of Medicine Tottori University

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• Regulation of the Expression of Epidermal Growth Factor Receptor mRNA with Thyroid Hormone L-3,5,3'-Triiodothyronine in Rat Hepatoma Cells

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