Methylated CpG Island Amplification of Representational Difference Analysis for Oral Cancer <Review>

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概要

• 論文の詳細を見る

• CpG islands are G+C-rich regions approximately 1 kb long that are free of methylation and contain the promoters of many mammalian genes. It has been demonstrated that aberrant methylation of CpG islands is associated with gene silencing of tumor suppressor genes. To examine DNA methylation changes in oral squamous cell carcinoma (OSCC), we have applied a novel genome screening technique, methylated CpG island amplification coupled with representational difference analysis. Using DNA from an OSCC cell line as tester and DNA from normal tongue tissue as driver, DNA sequences aberrantly methylated in OSCC can be obtained. We therefore propose that MCA is a useful technique to study methylation and to isolate CpG islands differentially methylated in cancer.

• 札幌医科大学の論文

著者

• TOYOTA Minoru

  Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University

• TOKINO Takashi

  Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University

• Tokino Takashi

  First Department Of Internal Medicine Molecular Biology Cancer Research Institute

• Tokino T

  Sapporo Medical Univ. Sapporo Jpn

• Tokino Takashi

  札幌医科大学 生化学

• Tokino T

  Department Of Molecular Biology Cancer Research Institute Sapporo Medical University School Of Medic

• Tokino Takashi

  札幌イムノダイアグノスティックラボラトリー

• OGI Kazuhiro

  Department of Oral Surgery, Sapporo Medical University

• Kohama Geniku

  Department of Oral Surgery, Sapporo Medical University School of Medicine

• Kohama G

  Sapporo Medical Univ. School Of Medicine Hokkaido Jpn

• Kohama Geniku

  Department Of Oral Surgery Sapporo Medical University School Of Medicine

• Tokino Takashi

  Department Of Molecular Biology Cancer Research Institute

• Tokino Takashi

  Department Of Molecular Biology Cancer Research Institute Sapporo Medical University

• Ogi Kazuhiro

  Department Of Oral Surgery Sapporo Medical University

• Toyota Minoru

  Department Of Biochemistry Cancer Research Institute

• Toyota Minoru

  First Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Kohama G

  Departments Of Oral Surgery Cancer Research Institute Sapporo Medical University School Of Medicine

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