Tamoxifen interacts with neu/c-erbB-2 receptor and inhibits growth of human malignant glioma cell lines

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概要

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• The effects of tamoxifen, an antiestrogen, on the inhibition of protein tyrosinephosphorylation in neu/c-erbB-2 receptor, DNA synthesis and proliferation wereevaluated using the malignant glioma cell lines U25 IMG and T98G whichoverexpressing neu/c-erbB-2. Pretreatment of two cell lines with tamoxifenresulted in a dose dependent inhibition of tyrosine phosphorylation as well asDNA synthesis and cell growth in two cell lines correlatively. The results supportthe hypothesis that activated protein tyrosine kinase receptors are involved in theproliferation of glioma cells. Tamoxifen may be useful in the treatment ofmalignant glioma.

• 神戸大学の論文

著者

• Tamaki Norihiko

  神戸大学医学系研究科

• Liu Zhenjun

  神戸大学医学部

• Kokunai Takasi

  神戸大学医学部

• Tamaki Norihiko

  神戸大学医学研究科

• Tamaki Norihiko

  神戸大学医学部

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• Tamoxifen interacts with neu/c-erbB-2 receptor and inhibits growth of human malignant glioma cell lines

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