Multiple Endocrine Neoplasia Type 1 Producing Growth Hormone- Releasing Factor in an Endocrine Pancreatic Tumor

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概要

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• We report a very rare case of multiple endocrine neoplasia type 1 (MEN 1) where a pituitary tumor presenting with acromegaly was associated with a growth hormone-releasing factor (GRF) producing pancreatic tumor. Twenty-seven months after surgery for pituitary adenoma, a 27-year-old male visited our hospital complaining of epigastralgia and back pain. Radiological examination revealed a 7-cm tumor in the pancreatic tail. Endocrinological studies revealed an abnormal increase in the level of growth hormone (GH). After resection of the pancreatic tumor, the GH level was normalized. Immunohistochemical studies confirmed the existence of GRF in the tumor. A diagnosis of GRF-producing pancreatic tumor was established. Nine months after surgery for the pancreatic tumor, the GH level remained normal and the pituitary gland had decreased in size. We speculate that secondary hyperpituitarism was caused by GRF produced by the endocrine pancreatic tumor in this case.

• 長崎大学の論文

著者

• Suga Kazuo

  Department Of Surgery Nishi-isahaya Hospital

• Yamashita Naohiro

  Second Department of Surgery, Nagasaki University School of Medicine

• Chiba Kenya

  First Department of Internal Medicine, Nagasaki University School of Medicine

• Yamashita Naohiro

  Second Department Of Surgery Nagasaki University School Of Medicine

• Chiba Kenya

  First Department Of Internal Medicine Nagasaki University School Of Medicine

関連論文

• Multiple Endocrine Neoplasia Type 1 Producing Growth Hormone- Releasing Factor in an Endocrine Pancreatic Tumor

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