Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia

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概要

• 論文の詳細を見る

• We evaluated the ventricular mechanical effects of PhosphodiesteraseIII (PDEIII) inhibitors in the failed heart after global ischemia induced by ventricular fibrillation (VF) using the left ventricular pressure-volume relationship (PVR). In 14 anesthetized open-chest dogs, left ventricular PVR was measured using a conductance catheter. Under administration of milrinone (MIL, n=7) and olprinone (OLP, n=7), the slopes of the LV end-systolic pressure-volume (Emax), arterial end-systolic pressure-stroke volume relations (Ea), ventriculoarterial coupling (Ea/Emax) and preload recruitable stroke work (PRSW) were obtained to evaluate changes in LV performance. The duration of VF was 1 min without cardiopulmonary bypass (CPB). OLP and MIL significantly increased the Emax and PRSW values in the failed heart after VF, and there was no dose-effect relationship at MIL doses of 0.25 to 0.75ﾎｼg/kg/min or at OLP doses of 0.1 to 0.3ﾎｼg/kg/min. The Ea/Emax value after VF was significantly lower in the presence of OLP or MIL than in the absence of these drugs (-45.3% with OLP and -46.5% with MIL). The results indicate that in the heart after transient global ischemia, both OLP and MIL improve hemodynamic and mechanical states in terms of ventriculoarterial coupling.

• 長崎大学の論文

著者

• Eishi Kiyoyuki

  Department Of Cardiovascular Surgery Graduate School Of Medicine Nagasaki University

• Tada Seiichi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Nagasaki University

• TADA Seiichi

  Cardiovascular Surgery, Nagasaki University School of Medicine

• Tada Seiichi

  Cardiovascular Surgery Nagasaki University School Of Medicine

• Tada Seiichi

  Department Of Cardiovascular Surgery Nagasaki University School Of Medicine

• Noguchi Manabu

  Department Of Cardiovascular Surgery Nagasaki Municipal Medical Center

• Noguchi Manabu

  Department Of Cardiovascular Surgery Nagasaki University School Of Medicine

• HAZAMA Shiro

  Sasebo City General Hospital

• Hazama Shirou

  Sasebo City General Hospital

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