Role of Arterial Blood Supply in Orthotopic Whole and Partial Liver Transplantaion in the Rat

概要

論文の詳細を見る
Aims: The hepatic artery (HA) thrombosis is a serious complication after liver transplantation (LT). In the present study, role of blood supply from HA to the grafted liver was experimentally investigated. Methods: Rats were grouped into 4: Group I-whole LT without HA reconstruction, Group II-partial (30%) LT without HA reconstruction, Group III - whole LT with HA reconstruction, and Group IV - partial (30%) LT with HA reconstruction. Results: In Group III, posttransplant elevation of serum levels of GOT and total bilirubin was minimal. Those levels in Groups I and II were significantly higher, compared to those in Groups III and IV. Dilatation of the bile duct and bile stasis were evident in 60% and 71% of rats in Group I and II, respectively. In Group II, histological examination demonstrated that proliferation of bile duct around the portal triad was prominent at early period after LT. Those findings were mild and there was no histological evidence of destruction of vascular and bile duct structures in Groups III and IV. Conclusion: These findings were suggestive that arterial blood flow to the grafted liver played an important role to feed nutrients to the biliary tree. In order to prevent damage in the biliary tract, successful reconstruction of HA is essential in LT.
長崎大学の論文