Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis
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概要
- 論文の詳細を見る
We investigated the clinical efficacy of low-dose and long-term 14-member macrolide therapy for 33 patients with Palomoplantar Pustulosis (PPP) most of whom showed a poor clinical response to topical corticosteroid and/or photo chemotherapy. After 4-12 weeks treatment with oral erythromycin (EM; 600mg/day) or clarithromycin (CAM ; 200 mg/day) in combination with previously used corticosteroid ointment, clinical evaluation was made on the basis of clinical score. Results are as follows: marked improvement ; 19 patients (57.6%), moderate improvement ; 7 patients, no clinical response ; 7 patients. There was no serious side effect during the observation period. In vitro studies suggest that CAM, a 14-member macrolide, significantly down-regulated IL-8 production by keratinocytes stimulated with combination of IFNホウ and TNFホア or staphylococcal-superantigen(SEB)and IFNホウ both at protein and mRNA levels. We would like to propose that low-dose and long-term 14-member macrolide therapy is effective and an alternate therapy for PPP with poor response to ordinal dermatological therapy of which mechanism is presumable inhibition of neutrophil chemotaxisis by inhibiting IL-8 production by keratinocytes.
- 長崎大学の論文
著者
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Sangjae Bae
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Matsunaga Yoshitake
Department of Dermatology, Nagasaki University School of Medicine
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Matsunaga Yoshitake
Department Of Dermatology Nagasaki University School Of Medicine
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Matsunaga Yoshitaka
Department of Dermatology, Nagasaki University School of Medicine
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Bae Sangjae
Second Department of Internal Medicine, Nagasaki University School of Medicine