Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand
スポンサーリンク
概要
- 論文の詳細を見る
We applied PCR strategies to detect the common types of ホア- thalassemia determinants which were associated with ホイ- thalassemia in northern Thailand. Two types of deletions in the ホア-globin gene locus;the 18 kb deletion of Southeast Asian type(-ホアSEA)and the 3.7 kb rightward deletion(-ホア3.7), and the most prevalent non-deletion mutation, Hb Constant Spring(ホアC8, TAA to CAA at the codon 141)were investigated in 22 cases of ホイ-thalassemia. Nine ホイ-thalassemia patients were found to be associated with one or two of these defective ホア-globin gene determinants and the mean hemoglobin concentration in these patients was 6.3 ツア 1.1 g/dl whereas it was 5.6ツア.0.8 g/dl in 12 ホイ-thalassemia patients without ホア- globin gene abnormalities ; the difference is statistically insignificant (p = 0.08). The level of anemia was severe in the ホイ-thalassemia patients carrying a single ホア-globin gene abnormality in the heterozygous compounds ; whereas the (ホイ-thalassemias withホア-globin gene defects in both alleles showed less severe anemia. A patient carrying the ホア ・」8 determinant in homozygous compound showed the highest hemoglobin level among these ホイ-thalassemia patients.
- 長崎大学の論文
著者
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Tsuyoshi Asato
Department Of Biochemistry University Of The Ryukyus Factury Of Medicine
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Asato Tsuyoshi
Department Of Biochemistry Faculty Of Medicine University Of Ryukyus
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Mika KUDEKEN
Department of Biochemistry, University of the Ryukyus Factury of Medicine
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Satoshi TSUDA
Department of Biochemistry, University of the Ryukyus Factury of Medicine
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Satoshi Tsuda
Department Of Biochemistry University Of The Ryukyus Factury Of Medicine
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Tsuda Satoshi
Department Of Materials Science And Engineering Graduate School Of Engineering Nagoya University
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Mika Kudeken
Department Of Biochemistry University Of The Ryukyus Factury Of Medicine
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Kudeken Mika
Department of Biochemistry, University of the Ryukyus Factury of Medicine
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