The ATP-Sensitive Potassium Channel Opener Alters MAC for Halothane but not for Isoflurane in Dogs

概要

論文の詳細を見る
Volatile anesthetics would exert their effects by acting at specific target proteins in the central nervous system. Neuronal membrane hyperpolarization brought about by increased potassium channel conductance is hypothesized to contribute to a mechanism of volatile anesthetic action. The purpose of this study was to determine whether the activation of ATP-sensitive potassium (K_<ATP>) channels might play a potential role in the mechanism of anesthetic action. Fourteen dogs were anesthetized with halothane or isoflurane. Following determination of the control minimum alveolar anesthetic concentration (MAC) of either anesthetic by a tail-clamp technique, KRN2391, a novel K_<ATP> channel opener, was infused intravenously at a dose of 3ﾎｼg . kg^<-1>.min^<-1> over 30 min and the MAC was determined again. The plasma concentration of KRN2391 was measured in all dogs. In additional 3 dogs the time courses of KRN2391 concentration in plasma and cerebrospinal fluid (CSF) were determined. The MAC for halothane was significantly reduced from 0.86ﾂｱ0.15% to 0.63ﾂｱ0.12% (P<0.01) by KRN2391 at a plasma level of 77 ng/ ml. In contrast the MAC for isoflurane was not altered by this compound. The CSF concentration of KRN2391 increased gradually during intravenous administration. The results suggest that activation of K_<ATP> channels would be involved in the mechanism of anesthetic action of halothane, whereas K_<ATP> channels would not play a role in isoflurane anesthesia.
長崎大学の論文

The ATP-Sensitive Potassium Channel Opener Alters MAC for Halothane but not for Isoflurane in Dogs

スポンサーリンク

概要

著者

関連論文

スポンサーリンク