The Relation of Prostate Tissue Protein Content, Nd : YAG Laser Transmissibility and Thermal Effect on Prostatic Hyperplasia

概要

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As our society ages, safe and minimally invasive treatment for the frequent occurrence of prostatic hyperplasia have been sought. We have performed prostatic hightemperature treatment for prostatic hyperplasia with the Prostalase using neodymium : yattriumaluminum garnet (Nd : YAG) laser for patients suffering from a bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). We used agars which included various densities of protein and skim milk as test materials to determine whether the exothermic mechanism of the Nd : YAG laser irradiation has an effect on protein molecules. By measuring the temperature inside the test materials and the irradiation transmissibility, we verified that in tissues with the same degree of color, the higher the protein content, the stronger the exothermic action of the Nd : YAG laser. In addition, in three human prostates obtained through pathological autopsy, the measurement of the protein content and the temperature inside the prostatic tissue in which prostatic thermal treatment had been performed showed that the exothermic action of the Nd : YAG laser varied according to the protein content: the higher the protein content, the stronger was the exothermic action. The present findings suggest that the temperature inside prostatic tissue reaches at least 60-65邃・with intissues with a protein content more than 23g/100g.
長崎大学の論文