Increased Expression of Proliferating Cell Nuclear Antigen in Rejecting Rat Lung Allografts

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概要

• 論文の詳細を見る

• The aim of this study was to investigate the expression of proliferating cell nuclear antigen (PCNA) as an index of cell proliferation in the Brown Norway (BN) to Lewis (LEW) rat lung allograft model.Following transplantation of BN left lungs into LEW recipients, counts of PCNA-positive cells in the perivascular cellular infiltrate and bronchus-associated lymphoid tissue (BALT) were compared with the histological grade of rejection. Lungs were excised on postoperative days 3 and 5. LEW-to-LEW donor-recipient transplantation was performed as a control. Routinely processed, paraffinembedded sections were selected and stained with PCNA. The PCNA index (% of nuclei positive for PCNA) in the BALT was significantly higher in allograft (19.1%, p < 0.05) compared with isograft (4.2%) at 3 days following transplantation. Similarly, the PCNA index was also greater in the perivascular cellular infiltrates of rejecting lungs (23.9% at 3 days, 31.6% at 5 days). These findings indicate that the cells stimulated by the rejection reaction could be increase the expression of PCNA, and the increasing severity of rejection was paralleled by an increase in the number of PCNA-positive cells. In conclusion, PCNA may be a useful marker of acute cellular rejection in lung allografts.

• 長崎大学の論文

著者

• Hiroyuki Oka

  First Department Of Surgery Nagasaki University School Of Medicine

• Sawada Takahiro

  First Department Of Surgery Nagasaki University School Of Medicine

• Takahiro Sawada

  First Depar-tment Of Surgery Nagasaki University School Of Medicine

• Takeshi Nagayasu

  First Department Of Surgery Nagasaki University School Of Medicine

• Nagayasu Takeshi

  First Department Of Surgery Nagasaki University School Of Medicine

• Oka Hiroyuki

  First Department of Surgery, Nagasaki University School of Medicine

関連論文

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• The Importance of Peripheral Blood Leukocytes and Macrophage Infiltration on Bronchial Wall Wound Healing in Rats Treated Preoperatively with Anticancer Agents
• Graft Damage After a Single Lung Transplantation for Pulmonary Hypertension in a Rat Model
• Concordant Lung Xenograft Rejection in a Hamster-to-Rat Model
• Increased Expression of Proliferating Cell Nuclear Antigen in Rejecting Rat Lung Allografts
• Lung Xenotransplantation in the Rat
• Effects of Induction Therapy on Wound Healing at Bronchial Anastomosis Sites in Rats
• Profile of Cytokine Production During the Inhibition of Acute Xenograft Rejection

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