Correlations between APACHE IIScore and Plasma Levels of Cytokines in Postsurgical Patients

概要

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This study was designed to assess whether plasma cytokines correlated with the clinical status of postsurgical patients. Plasma levels of cytokines in 72 patients admitted to the intensive care unit were measured using an Enzyme Linked Immuno Solubent Assay. The clinical status was evaluated with the Acute Physiology Age and Chronic Health Evaluation (APACHE) 11 scoring system. There were significant correlations between the APACHE 11 score and the plasma levels of Tumor Necrosis Factor(TNF)α and interleukin(IL)-1 β.But IL-8 and IL-6 did not correlate with the APACHE II score. Three patients died within postoperative 20 days. The plasma levels of TNF α,IL-1,β,IL-8 and IL-6 were significantly higher in nonsurvivors than in survivors. There was no significant difference in the APACHE II score and the plasma levels of IL-1β,IL-8 and IL-6 between the survivors with Systemic Inflammatory Response Syndrome (SIRS) and those without SIRS. The survivors without SIRS had a higher concentration of TNFα than those with SIRS. The results indicate that TNF α and IL-1 β correlate well with the severity of illness in the postsurgical patients, whereas IL-8 and IL-6 does not.
長崎大学の論文