Effect of Platelet-Activating Factor Antagonist (TCV-309) on Survival in the Canine Double Lung Transplantation Model
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概要
- 論文の詳細を見る
Fourteen adult mongel dogs were subjected to sequential double lung transplantation. The animals were assigned randomly to three experimental groups. Four dogs served as the control group (no treatment). Four other dogs were flushed with 4°C University of Wisconsin (UW) solution (UW flush group). The remaining six dogs were treated with platelet-activating factor antagonist (TCV-309) (PAF- antagonist group). None of the animals in the control group or the UW flush group survived more than 6 hours after transplantation. In contrast, all of the dogs in the PAF- antagonist group were extubated. The mean survival in this group was 5.2 days. PAF-antagonist (TCV-309) preserved lung function and improved survival in the canine sequential double lung transplantation model.
- 長崎大学の論文
著者
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TAKAHASHI Takao
the First Department of Surgery, Nagasaki University School of Medicine
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YAMAMOTO SATOSHI
First Department of Surgery, Nagasaki University School of Medicine
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TAKAHASHI TAKAO
First Department of Surgery, Nagasaki University School of Medicine
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KAWAHARA Katsunobu
Second Department of Surgery, Fukuoka University School of Medicine
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Takahashi Takao
The First Department Of Surgery Nagasaki University School Of Medicine
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Yamamoto Satoshi
First Department Of Surgery Nagasaki University School Of Medicine
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Kawahara Katsunobu
Second Department Of Surgery Fukuoka University School Of Medicine
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