Neoadjuvant chemotherapy and bladder preservation for invasive bladder cancer
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概要
- 論文の詳細を見る
A total of 16 patients with muscle invasive bladder cancer, clinical stage T2N0M0 (6), T3aN0M0 (7) or T3bN0M0 (3), underwent 1 to 4 cycles of neoadjuvant cisplatin-based chemotherapy followed by either partial cystectomy or transurethral resection. The overall response rate to the chemotherapy was 56% (95% confidence limits 32 to 79%). For the stages T2 and T3a cancer patients the overall response rate was 69%, while all 3 patients with T3b cancer showed incomplete response. Ten (63%) of 16 patients relapsed. Recurrence of superficial bladder cancer was observed in 5 patients with T2G2-3 or T3aG2 tumors, whereas invasive bladder cancer or metastases developed in 5 patients with T3a-3bG3 tumors. Eleven (69%) patients are alive with a functional bladder at a median followup of 48 months+. While bladder preservation may be permitted in selected patients with T2-3a disease, it is inconclusive whether neoadjuvant chemotherapy improves the survival of patients with invasive bladder cancer.
- 島根大学の論文
著者
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Usui T
Hiroshima Univ. Hiroshima Jpn
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Igawa M
Department Of Urology Shimane University School Of Medicine
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Shiina Hiroaki
Shimane University
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Igawa Mikio
Shimane University
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Shirakawa Hiroki
Department Of Urology Shimane University School Of Medicine
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Urakami Shinji
Department Of Urology Shimane University School Of Medicine
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Urakami Shinji
Shimane Medical University
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Shirakawa Hiroki
Shimane Medical University
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Ishibe Tomoyuki
Shimane Medical University
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Usui Tsuguru
Hiroshima University School of Medicine
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Kadena Hitoshi
Hiroshima University School of Medicine
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