INVESTIGATION OF POST-TRANSCRIPTIONAL EVENTS OF THE THYROGLOBULIN IN THE THYROID GLAND OF THE HYPOTHYROID GROWTH-RETARDED MOUSE DW/J-GRT

概要

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The DW/J-grt mouse is a mutant model exhibiting hypothyroidism and dwarfism. The phenotype of the DW/J-grt mouse is similar to that of the DW/J-dw mouse. However, the grt locus was previously mapped to mouse chromosome (Chr) 5 and shown to be different from the dw locus (Chr 16). Here, we investigated the morphology of the thyroid gland and functions of the thyroid gland in DW/J-grt mouse, particularly, the synthesis, transportation, secretion, and iodine incorporation of thyroglobulin (Tg). Morphological analysis showed hypogenesis of follicles in the DW/J-grt thyroid. The investigation of the Tg elucidated that DW/J-grt mouse showed no significant difference from normal mouse with respect to the expression, synthesis, transportation and secretion. The uptake of iodine in the thyroid gland of DW/J-grt mouse is markedly lower when comparing with normal mouse, but the incorporation ratio of iodine into Tg was not different between DW/J-grt and normal mice. These results suggest that responsible gene for the hypothyroidism of DW/J-grt mouse is not attributed to the Tg gene nor the genes that support the post-transcriptional events of Tg.
名古屋市立大学の論文
2002-04-30