COMPARISON OF SYSTEMIC AND MUCOSAL RESPONSES OF MICE TO ALUMINIUM-ADSORBED DIPHTHERIA TOXOID BETWEEN INTRANASAL ADMINISTRATION AND SUBCUTANEOUS INJECTION

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We investigated the effect of aluminium compound as an adjuvant on systemic and mucosal immune responses of mice vaccinated intranasally and subcutaneously with aluminiumadsorbed diphtheria toxoid (aDT). Intranasal immunization with aDT induced high levels of DT-specific serum IgG and IgA antibody titers and lower levels of DT-specific serum IgE antibody responses in comparison with subcutaneous injection. High or moderate levels of mucosal DT-specific IgA antibody responses were observed in the lung, the nasal cavity, the small intestine, the fecal extract and the vagina. On the other hand, subcutaneous inoculation of aDT elicited high levels of serum DT-specific IgG antibody titers but hardly induced mucosal IgA antibody responses to DT at all mucosal sites examined. These results suggest that aluminium compound may act as a mucosal adjuvant and intranasal administration of aDT seems to be better than its subcutaneous injection with respect to additional protection at the mucosal sites, decreasing IgE mediated allergic reactions, and simpler inoculation procedure.
2001-09-01