<SYMPOSIUM : Biology of Aging and Age-associated Skin Disorders>AGING IN EPIDERMAL MELANOCYTES
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概要
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This review article summarized the clinico-morphological association on aging of human melanocytes, with a new insight into the effects of cutaneous nervous system on melanocytes during aging. Skin aging is divided into chronoaging and photoaging. Photoaged skin has characteristic clinical, morphological and biological features that are distinct from chronologically aged skin. With aging, there are a gradual decrease in the number of epidermal melanocytes and reduction of melanogenetic activity. Epidermal melanocytes in chronoaging are characterized by a mosaic population manifested by the heterogeneous appearance of melanocytes. In contrast, photodamaged melanocytes are predominantly active cells with an admixture of degenerate cells, resulting in irregular pigmentation caused by progressive loss of melanocytes as well as by reactive melanocytic hyperplasia. Ultrastructural observations reveal that there are remarkable differences in the morphology of melanocytes between photoaged and intrinsically aged skin, and support the concept that photoaging processes contribute to cytological alterations in melanocytes. Senile pigment freckle and leukoderma senilis commonly occur during aging, and their morphological features as well as pathogenesis are in marked contrast each other. Because distinction of lentigo maligna and melanocytic hyperplasia in photodamaged skin is a frequent problem in dermatopathology, we propose new criteria using ultrastructure and cytomorphometry of melanocytes, which are sharply distinguished between these two lesions. We demonstrate intimate interaction between cutaneous nervous system, especially a neuropeptide calcitonin gene-related peptide and nerve growth factor, and melanocytes within the epidermal environment in photoaging processes.
- 名古屋市立大学の論文
- 2000-01-31
著者
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Luo Y
Shanghai Jiaotong Univ. Chn
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MOROHASHI Masaaki
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Luo Y
Osaka University:shanghai Jiaotong University
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Luo Yu
Department Of Dermatology Toyama Medical And Pharmaceutical University
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TOYODA Masahiko
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Toyoda Masahiko
Department Of Dermatology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Toyoda M
Department Of Dermatology Toyama Medical And Pharmaceutical University
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Morohashi M
Toyama Medical And Pharmaceutical Univ. Toyam Jpn
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Morohashi Masaaki
Department Of Dermatology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Morohashi Masaaki
Department Of Dermatology Toyama Medical & Pharmaceutical University
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