<Originals>Mutants of Saccharomyces cerevisiae Defective in Sexual Cell Agglutination

概要

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Eight mutants of Saccharomyces cerevisiae defective in sexual agglutination were isolated to study the genetic control of sexual agglutination. These mutants also failed to undergo cell fusion, resulting in no zygotes. Among them, 6 mutants lost their ability to respond to mating pheromone. Others were defective not only in response to mating pheromone but production of it. In these mutants, the activity of sex-agglutinin responsible for sexual agglutination could not be detected both in cytoplasmic and cell wall fractions. These mutations may involve the synthesis of sex-agglutinin. Genetic analyses indicate that the phenotype is controlled by a single nuclear gene whose expression is non-specific for mating type. Two mutations were mapped on chromosome VIII. Defect in sexual agglutinability of the mutants was concomitantly segregated with defect in cell fusion, and with insensitivity to mating pheromone and production of it.
1984-06-28