<Originals>Effect of ventricular fibrillation under hypothermia on myocardial protection in isolated rabbit hearts

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A combined effect of ventricular fibrillation (VF) and hypothermia on myocardial protection was studied in isolated rabbit hearts. To evaluate the effect, inorganic phosphate (Pi), creatine phosphate (CrP), and adenosine triphosphate (ATP) were measured to determine recovery levels from organic damage after ischemia and reperfusion. ^<31>Phosphorus nuclear magnetic resonance (^<31>P-NMR) spectra were used to measure intramyocardial high-energy phosphates noninvasively and continuously. Forty-four isolated rabbit hearts were used for eight experiments as follows. Group 1 was treated by VF for 60 minutes of ischemia at 37℃, group 2 by VF for 60 minutes of ischemia at 28℃, group 3-A by VF for 60 minutes of ischemia at 20℃, group 3-B by VF for 120 minutes of ischemia at 20℃, group 4-A by global ischemia for 60 minutes with 10℃ Young's solution and cold blood cardioplegia (CBC), group 4-B by global ischemia for 120 minutes with 10℃ Young's solution and CBC, group 5-A by non-working at 20℃ for 60 minutes and group 5-B by non-working at 20℃ for 120 minutes. Each group was treated by reperfusion for 20 minutes after ischemia. In group 3-A, the recovery of ATP (93.2±3.6%) was excellent after 20 minutes of reperfusion. The difference among the recovery of ATP in groups 1,2 and 4-A was significant (p<0.05). In group 3-B, however, the recovery of ATP after 20 minutes of reperfusion was poor with value of 56.0±14.7%. These results suggest that VF, previously considered harmful, is beneficial to myocardial protection during ischemia within 60 minutes under the hypothermic conditions of 20℃.
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<Originals>Effect of ventricular fibrillation under hypothermia on myocardial protection in isolated rabbit hearts

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