Involvement of Rho-Kinase Activation in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Patients With Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background: Activation of Rho-kinase plays a central role in the pathogenesis of drug-eluting stents (DES)-induced coronary hyperconstricting responses in pigs in vivo has been previously demonstrated. In the present study, Rho-kinase activation involved in those responses in patients with coronary artery disease (CAD) is examined. Methods and Results: In 24 patients with CAD who underwent coronary intervention with either DES or bare-metal stents (BMS), coronary vasomotor responses to intracoronary acetylcholine (ACh) before and after intracoronary pre-treatment with a Rho-kinase inhibitor, fasudil was examined. Coronary vasomotor responses by quantitative coronary angiography (QCA) and coronary vascular structure by optical coherence tomography (OCT) was evaluated. QCA showed that the coronary vasoconstricting responses to ACh were significantly enhanced in the DES group compared with the BMS group both at the proximal and the distal segments adjacent to the stents (proximal: BMS –13.0±10.7% vs. DES –25.4±14.3%, P=0.036; distal: BMS –24.4±12.2% vs. DES –43.8±14.7%, P=0.003). Importantly, fasudil markedly attenuated the enhanced vasoconstricting responses to ACh in the DES group (proximal 10.2±11.7%, distal 14.4±10.5% vs. before fasudil, both P<0.01). In the OCT imaging analysis, there was no significant correlation between intimal thickness and coronary vasoconstriction to ACh. Conclusions: These results indicate that Rho-kinase activation is substantially involved in the pathogenesis of the DES-induced coronary hyperconstricting responses in patients with CAD, suggesting the therapeutic importance of Rho-kinase pathway. (Circ J 2012; 76: 2552–2560)
- 2012-10-25
著者
-
KIKUCHI Yoku
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
-
AIZAWA Kentaro
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
-
TAKII Toru
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
-
Ito Kenta
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Takeda Morihiko
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Tsuburaya Ryuji
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Kikuchi Yoku
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Aizawa Kentaro
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Ito Yoshitaka
Department Of Cardiology Aichi Medical University
-
Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
-
Nakayama Masaharu
Department Of Applied Chemistry Faculty Of Engineering Yamaguchi University
-
Takii Toru
Department Of Cardiology Matsusaka Central General Hospital
-
Takahasi Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
-
Yasuda Satoshi
Department Of Biochemistry Sapporo Medical University School Of Medicine
-
Shimokawa Hiroaki
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
-
Nakayama Masaharu
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
-
ITO Yoshitaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
関連論文
- Reduced Perioperative Immune Response in Video-Assisted Versus Open Surgery in a Rat Model
- Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris
- PJ-302 High-Resolution Measurement of Carotid Artery Wall Elasticity for Clinical Tailor-Made Risk Management of Arteriosclerosis(Atherosclerosis, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Treatment with Eicosapentaenoic Acid Improves Exercise-Induced Vasodilation in Patients with Coronary Artery Disease
- Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
- Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan : Report From the MIYAGI-AMI Registry Study
- Evidence for Rho-Kinase Activation in Patients With Pulmonary Arterial Hypertension
- PJ-477 Diagnostic Usefulness of Vasodilator Test with Inhaled Nitric Oxide in Patients with Pulmonary Veno-Occlusive Disease(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- PE-445 Renin-Angiotensin System Plays an Important Role in Diabetes Mellitus-Induced Diastolic Dysfunction in Hypertensive Rats(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- PE-444 Prognostic Impact of Myocardial Fibrosis in Systolic Heart Failure : New Aspect of Usefulness of Myocardial Biopsy(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-349 Gender Difference in the Responsiveness to Corticosteroid Therapy in Patients with Cardiac Sarcoidosis(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-129 Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice(PE022,Atherosclerosis, Basic (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Optical Coherence Tomography as a Novel Diagnostic Tool for Distal Type Chronic Thromboembolic Pulmonary Hypertension
- PJ-912 Assessing the Severity of Valvular Aortic Stenosis by Magnetic Resonance Imaging (Phase-Contrast Imaging)(MRI / MRA(04)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Current Status of Vasospastic Angina in Japan : An Interim-report of the Multicenter Registry of the Coronary Spasm Association of Japan(Recent Progress in the Management of Vasospastic Angina,Meet the Expert 6 (ME-6) (IHD),The 73rd Annual Scientific Me
- 2 Microvascular Angina : Invisible but Important Player in Cardiovascular Gender Medicine(Recent Progress of Gender-specific Medicine in Cardiology,Meet the Expert 4 (ME-4) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Lamin A/C Gene Mutations in Familial Cardiomyopathy with Advanced Atrioventricular Block and Arrhythmia
- Importance of Dual Induction Tests for Coronary Vasospasm and Ventricular Fibrillation in Patients Surviving Out-of-Hospital Cardiac Arrest
- 1 Importance of Medical Treatment for Vasospastic Angina : Lessons from Multicenter Registry by Coronary Spasm Association of Japan(Therapeutic Decision Making for Coronary Artery Disease Among PCI, CABG, and Medication,Symposium 3 (SY-03) (IHD),The 73rd
- Electrophysiological Properties of the Right Atrial Septum in Patients with Atrial Tachyarrhythmias
- OJ-261 Hydrogen Peroxide Derived from Beating Heart Mediates Coronary Microvascular Dilatation during Tachycardia in Dogs in Vivo(Coronary circulation, basic/clinical-2 (IHD) OJ44,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting
- OE-218 Risk Factors and Incidence of Pulmonary Embolism in Japan 2004(Thromboembolism/Antithrombotic therapy/Thrombolysis-1 (H) OE37,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats
- PJ-171 Pravastatin Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension Through Down-regulation of Stromal Cell-Derived Factor-1 in Mice(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- Prognostic Importance of Chronic Kidney Disease in Japanese Patients With Chronic Heart Failure : Implications of the CHART Study
- PE-483 Prognostic Impact of Central Sleep Apnea in Patients with Chronic Heart Failure(Heart failure, clinical-9 (M) PE81,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-385 End-tidal Carbon Dioxide Predicts the Responsiveness of Patients with Chronic Heart Failure Associated with Central Sleep Apnea to Oxygen Therapy(Heart failure, clinical-6 (M) OJ65,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific
- OJ-247 Chronic Hypoxia Mobilizes Smooth Muscle Progenitors in Mice(Vascular smooth muscles-1 (H) OJ42,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-103 Therapeutic Importance of Angiotensin-Converting Enzyme Inhibitor and/or Angiotensin Receptor Blocker in Patients with Diastolic Heart Failure(Heart failure, clinical-4 (M) OJ18,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Me
- OE-168 Hemoglobin Level Predicts Sudden Death in Patients with Diastolic Heart Failure(Heart failure, clinical-1 (M) OE28,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Accumulated Risks and Non-Optimum Medical Treatment in Japanese Older Patients with Chronic Heart Failure : Results from the CHART Study(Characteristics and Management Strategies of Chronic Heart Failure in the Japanese,Symposium 12 (SY12) (M),The 70th
- PE-171 Co-existence of Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest(PE029,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-004 Significance of Basal Coronary Artery Tone in Patients with Vasospastic Angina : Analysis by Using Quantitative Coronary Angiography(Angina pectoris, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
- OE-393 Importance of Dual Induction Test for Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest(Emergency care/CPR(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
- PJ-759 Equivalent Inhibitory Effects of 4.0-mm-Diameter Bare Metal Stent with 3.5-mm-Diameter Drug-eluting Stent to Prevent Restenosis after Percutaneous Coronary Intervention(Coronary revascularization, PCI-22, The 71st Annual Scientific Meeting of the J
- PJ-329 Low-dose of Thyroid Hormone Restores Depressed Contractility and Impaired Calcium Handling in Chronically Unloaded Heart in Rats(Cardiac function, basic/clinical-4 (M) PJ56,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
- Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy
- PJ-731 Genetic Disruption of All Nitric Oxide Synthase Isoforms Causes Accelerated Renal Lesion Formation in Mice in Vivo(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- PJ-693 Inhibition of Sodium Channels Enhances Arrhythmogenic Regional Endocardial Substrate in Patients with Brugada Syndrome(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The J
- PJ-533 Role of H_2O_2 as an Endogenous EDHF during Coronary Occlusion and Injection of Erythropoietin in Canine Coronary Native Collateral Microvessels(PJ090,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Poster Session (Japanese),Th
- PJ-234 Usefulness of Cardiac Magnetic Resonance Imaging to Evaluate Cardiac Dyssynchrony in Patients with Chronic Heart Failure(PJ040,CRT/ICD 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-188 Combination Therapy with an Angiotensin Receptor Blocker and a Calcium Channel Blocker Improves EDHF-Mediated Responses in Diabetic Apolipoprotein E-Deficient Mice(PJ032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 1 (H),Poster
- PE-451 Extracorporeal Cardiac Shock Wave Therapy Ameliorates Left Ventricular Remodeling after Myocardial Ischemia-Reperfusion Injury in Pigs in Vivo(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circul
- OJ-046 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension(OJ08,Pulmonary Circulation (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 3 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 5 Differential Roles of Progenitor Cells in the Arterial Development of the Abnormal Vasculature(Young Investigator's Award Finalists Lectures (YIA),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-100 Role of Rho-kinase in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Paclitaxel-Eluting Stent(OE17,Coronary Revascularization, PCI (Restenosis/Others/DES) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- 3 Protective Role of Endogenous Erythropoietin-erythropoietin Receptor System in the Development of Heart Failure(The Mechanism and Management of Cardio-renal Risk,Roundtable Discussion 3 (RT-3) (H),The 73rd Annual Scientific Meeting of The Japanese Circu
- FRS-068 Deletion of Endogenous Erythropoietin System in Non-Hematopoietic Cells Impairs Development of Coronary Angiogenesis and Enhances Susceptibility to Pressure-Overload-Induced Heart Failure(Heart Failure, Cardiac Remodeling and Cardiomyopathy 1, The
- OJ-175 High-Dose Statin Therapy Ameliorates Hypoxia-Induced Pulmonary Hypertension through Suppression of the SDF-1/CXCR4 Axis(Pulmonary circulation-2 (H) OJ30,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- Endogenous Plasma Erythropoietin May Limit Infarct Size by Preventing Apoptosis Through Erythropoietin-Erythropoietin Receptor Signaling in Non-hematopoietic Lineage(Myocardial Ischemia-reperfusion, Basic 1 (IHD), The 69th Annual Scientific Meeting of the
- OJ-318 Important Role of Endogenous Erythropoietin System to Recruit Endothelial Cells in Hypoxia-Induced Pulmonary Hypertension in Mice(Growth factor/Cytokine-1 (H) OJ53,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the J
- OJ-245 Molecular Mechanism for the Protective Effect of Endogenous Erythropoietin-Erythropoietin Receptor System against Myocardial Ischemia/Reperfusion Injury(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70t
- OJ-184 Impaired Mobilization and Incorporation of Progenitor Cells into the Ischemic/Hypoxic Tissues in Erythropoietin Receptor-Knockout Mice(Regeneration (angionenesis/myocardial regeneration)-3 (M) OJ31,Oral Presentation (Japanese),The 70th Anniversary
- OJ-168 Important Protective Role of Endogenous Erythropoietin System in Ischemic Cardiovascular Disease(Endothelium-2 (H) OJ28,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-130 Important Protective Role of Endogenous Erythropoietin System against Pressure Overload-Induced Left Ventricular Dysfunction in Mice in Vivo(Heart failure, basic-1 (M) OE22,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting
- 2 Deficiency of Erythropoietin Receptor Gene in Non-hematopoietic Lineage Deteriorates Cardiac Function and Survival in Ventricular Pressure Overload in Mice(Molecular Mechanism of Hypertensive Heart Failure,Symposium 5 (SY5) (H),The 70th Anniversary Annu
- FRS-167 Absence of Erythropoietin Receptor Gene in Non-hematopoietic lineage Deteriorates Left Ventricular Remodeling after Myocardial Ischemia and Reperfusion(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- Myocardial phosphoinositide turnover can be assessed by positron emission tomography with C-11-labelled diacylglycerol in patients with myocardial infarction
- OE-200 Postnatal Deletion of Nkx2-5 Causes Slowly Progressive Impairment of Cardiac Conduction and Contraction in Mice(OE34,Cardiac Function (Basic) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-206 Long-Term Treatment with Eicosapentaenoic Acid Suppresses Ischemia-Induced Ventricular Fibrillation in Pigs in Vivo : Possible Involvement of ATP-Sensitive Potassium (KATP) Channel(PE035,Cardiovascular Pharmacology (Basic) (H),Poster Session (Engli
- PJ-033 Long-Term Treatment with Eicosapentaenoic Acid Suppresses Ventricular Fibrillation in Acute Myocardial Infarction in Pigs : Evaluation with Monophasic Action Potential(Arrhythmia, therapy(23)(A),Poster Session(Japanese),The 72nd Annual Scientific M
- OE-293 Enhanced Pulsatile Pressure Accelerates Vascular Smooth Muscle Migration : Implications for Atherogenesis of Hypertension(Vascular smooth muscle (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- Extracorporeal Shock Wave Therapy Ameliorates Hindlimb Ischemia in Rabbits
- PE-087 Long-term Treatment with Eicosapentaenoic Acid Suppresses Coronary Vasoconstriction and Ventricular Fibrillation in a Porcine Model of Acute Myocardial Infarction(Acute coronary syndrome, basic/clinical-3, The 71st Annual Scientific Meeting of the
- PE-043 Hemodynamic Factors Accelerate Vascular Smooth Muscle Migration Through IP3-Receptor : Implication for Atherogenesis of Hypertension(Atherosclerosis, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 7 Extracorporeal Cardiac Shock Wave Therapy As a New, Non-invasive Angiogenic Strategy for End-Stage Coronary Artery Disease(Clinical Trials of Regeneration Therapy in Japan, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- IS152 Imaging of phosphoinositide turnover in the ventricular remodeling after myocardial infarction
- Should Increasing the Dose or Adding AT1 Receptor Blocker Follow the Early Initiation of ACE Inhibitor in Acute Myocardial Infarction?
- PJ-142 Monitoring Impedance Drop is the Only Way to Avoid Pop Phenomenon during Catheter Ablation(PJ024,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- PE-372 Anatomical Relationship between Pulmonary Vein and Esophagus Evaluated by 64-slice Multi-Detector Computed Tomography : Pulmonary Vein Isolation Avoiding Esophagus is Possible?(Arrhythmia, therapy(09)(A),Poster Session(English),The 72nd Annual Scie
- PE-371 The Eveluation of Accessory Appendages in Left Atrium by 64-slice Multi-Detector Computed Tomography Angiography(Arrhythmia, therapy(09)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Proptosis Caused by Partially Thrombosed Orbital Varix of the Superior Orbital Vein Associated With Traumatic Carotid-Cavernous Sinus Fistula : Case Report
- Dumbbell-shaped osteochondroma of the fifth rib causing spinal cord compression
- Electroless Formation of Pressure Sensitive Thin Films of Platinum Porphyrin Using Surfactants with an Azobenzene Group
- Low-dose Thyroid Hormone Rescues Depressed Contractility in Chronically Unloaded Hearts(Cardiac Function, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-191 Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice(Atherosclerosis, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-537 Evidence for Mobilization of Vascular Progenitor Cells in Patients with Pulmonary Hypertension(Regeneration (angionenesis/myocardial regeneration)-4 (M) PE90,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- OE-135 Impaired Angiogenic Response to Acute Hindlimb Ischemia in Erythropoietin Receptor-Knockout Mice(Peripheral circulation-1 (H) OE23,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-088 Myocardial delayed enhancement detected by MRI was related with the long-term prognosis in patients with nonischemic dilated cardiomyopathy(X-ray/CT/MRI/DSA 1 (I) : OE11)(Oral Presentation (English))
- Beta Adrenergic Signaling Pathway Is Not Impaired in Chronically Unloaded Hearts
- Chronic cardiac unloading leads to a time-dependent depression of myocyte contractile function and calcium regulation
- Visualization of Myocardial Fibrosis Using Contrast-Enhanced Magnetic Resonance Imaging in Patients with Dilated Cardiomyopathy
- FRS-023 Chronic Cardiac Unloading Results in Enhancement of α 1 Adrenergic Signaling and Contractile Response in Isolated Myocytes(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
- Autoimmunity to citrullinated type II collagen in rheumatoid arthritis
- Long-Term Treatment With Eicosapentaenoic Acid Ameliorates Myocardial Ischemia-Reperfusion Injury in Pigs In Vivo : Involvement of Rho-Kinase Pathway Inhibition
- Protective Effects of Recombinant Human Erythropoietin against Pressure Overload-Induced Left Ventricular Remodeling and Premature Death in Mice
- Urbanization, Life Style Changes and the Incidence/In-Hospital Mortality of Acute Myocardial Infarction in Japan : Report From the MIYAGI-AMI Registry Study
- Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication
- Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease
- Current Perspectives on Protective Roles of Erythropoietin in Cardiovascular System : Erythropoietin Receptor as a Novel Therapeutic Target
- Involvement of Rho-Kinase Activation in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Patients With Coronary Artery Disease
- Enhanced Rho-Kinase Activity in Patients With Vasospastic Angina After the Great East Japan Earthquake
- Effect of the Great East Japan Earthquake on Cardiovascular Diseases:– Report From the 10 Hospitals in the Disaster Area –
- Rho-Kinase Activation in Patients With Heart Failure
- SOLUBILITIES OF GASES IN AQUEOUS SOLUTIONS OF WEAK ACIDS
- Effect of the Great East Japan Earthquake on Cardiovascular Diseases : Report From the 10 Hospitals in the Disaster Area
- Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease
- In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging:– Validation Study –
- Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice : A critical role of endothelial nitric oxide synthase