Somatic Reactivation of Expression of the Silent Maternal Mest Allele and Acquisition of Normal Reproductive Behaviour in a Colony of Peg1/Mest Mutant Mice

スポンサーリンク

概要

• 論文の詳細を見る

• Genomic imprinting confers allele-specific expression in less than 1% of genes, in a parent-of-origin specific fashion. In humans and mice the Peg1/Mest gene (Mest) is maternally repressed, and paternally expressed. Mest is expressed in embryogenic mesoderm-derived tissues and in adult brain, and paternal mutations in Mest lead to growth retardation and defective maternal behaviour. Despite our current understanding of mechanisms associated with the establishment of imprinting of Mest and other imprinted genes, it is unclear to what extent Mest imprinting needs to be maintained in adult tissues. Aberrations of imprinting are known to occur in certain rare syndromes, and involve either inherited mutations, or constitutive epigenetic alterations occurring soon after fertilization. Imprinting abnormalities may also occur in the aging somatic tissues of adult individuals. Here we report an occurrence of post-embryonic somatic variability of Mest allelic expression in a colony of mice where heterozygotes at the imprinted Mest locus for a mutation inherited from the father spontaneously expressed the normally silenced allele from the mother. In addition, a newly acquired ability to overcome the deficit in maternal reproductive behaviour had occurred in the mutant mice, but this appeared not to be directly linked to the Mest mutation. Our results suggest that at least one allele of Mest expression is required in the somatic tissues of adult individuals and that under certain conditions (such as in the presence of a Mest insertional mutation or in an altered genetic background), somatically acquired alterations of allelic expression at the Mest locus may occur.

• 2012-08-01

著者

• Slobbe Lynn

  Department Of Microbiology University Of Otago

• ROBSON Ewan

  Department of Pathology, University of Otago

• ECCLES Michael

  Department of Pathology, University of Otago

• INESON Jessica

  Institute for Molecular Bioscience, University of Queensland

• STAYNER Cherie

  Department of Pathology, University of Otago

• HAZLETT Jody

  Department of Pathology, University of Otago

• LEGGE Michael

  Department of Pathology, University of Otago

• LEGGE Michael

  Department of Biochemistry, University of Otago

関連論文

• IL-2 linked to a peptide from influenza hemagglutinin enhances T cell activation by affecting the antigen-presentation function of bone marrow-derived dendritic cells
• Somatic Reactivation of Expression of the Silent Maternal Mest Allele and Acquisition of Normal Reproductive Behaviour in a Colony of Peg1/Mest Mutant Mice
• Changes in Glycoconjugate-Lectin Binding Characteristics of in vitro and in vivo Mouse Blastocysts
• Mid-Second Trimester Organic Acids in Severe Open Neural Tube Defects

スポンサーリンク