Cathepsin K-upregulation in fibroblasts promotes matrigel invasive ability of squamous cell carcinoma cells via tumor-derived IL-1α
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概要
- 論文の詳細を見る
Background: Cathepsin K (CTSK), a cysteine protease with strong collagenolytic properties, is involved in extracellular matrix turnover. In the previous studies, CTSK expression was detected in peritumoral fibroblasts (Fbs) around squamous cell carcinoma (SCC), but not in those surrounding benign epidermal tumors. However, the mechanism governing CTSK expression in epidermal tumors remains unclear. Objective: To study the regulatory mechanisms of fibroblastic CTSK expression in the SCC-stromal interaction. Methods: We examined dynamic interactions of Fbs with tumorigenic SCC cells (A431 and A253) or normal human keratinocytes. Results: SCC cells and normal keratinocytes did not synthesize CTSK, while Fbs constitutively expressed CTSK. When cocultured, SCC cells upregulated fibroblastic CTSK expression more potently than did normal keratinocytes, which was mainly attributable to SCC-derived IL-1α. Coculturing Fbs with SCC cells significantly augmented the matrigel invasive ability of SCC cells, which was downregulated when cocultured with CTSK knockdown Fbs or in the presence of neutralizing anti-IL-1α antibody. Conclusion: The CTSK-upregulated Fbs generated by SCC-derived IL-1α may play a crucial role in the progression and invasion of SCC.
- Elsevier Irelandの論文
- 2011-01-01
著者
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FURUE Masutaka
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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Furue Masutaka
中華人民共和国
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Moroi Yoichi
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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Masuda Teiichi
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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Takeuchi Satoshi
Department Of Cardiology Kanazawa Medical University
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Furue M
Kyushu Univ. Fukuoka
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Furue Masutaka
Department Of Dermatology Kyushu University Graduate School Of Medicine
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UCHI Hiroshi
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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HAYASHIDA Sayaka
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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NAKAHARA Takeshi
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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Uchi Hiroshi
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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Uchi Hiroshi
Department Of Dermatology Graduate School Of Medical Science Kyushu University
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Furue Masutaka
Department Of Dermatology Faculty Of Medicine Kyushu University
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Moroi Yoichi
Department Of Dermatology Graduate School Of Medical Science Kyushu University
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TSUJI Gaku
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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XIE Lining
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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Nakahara Takeshi
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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Nakahara Takeshi
Department Of Dermatology Kyushu University School Of Medicine
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Furue Masutaka
Faculty Of Medical Sciences Department Of Dermatology Kyushu University
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Tsuji Gaku
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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Xie Lining
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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SHAN Baoen
Research Center, The Fourth Hospital of Hebei Medical University
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Hayashida Sayaka
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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Shan Baoen
Research Center The Fourth Hospital Of Hebei Medical University
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Takahara Masakazu
Department Of Dermatology Graduate School Of Medical Sciences Kyushu University
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TAKEUCHI Satoshi
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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