Impact of Functional, Morphological and Clinical Parameters on Epicardial Adipose Tissue in Patients With Coronary Artery Disease

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概要

• 論文の詳細を見る

• Background: Because a close relationship between epicardial adipose tissue (EAT) and coronary artery disease (CAD) has been shown, the impact of functional, morphological and clinical parameters to identify potential determinants of EAT was investigated. Methods and Results: Clinical and cardiac magnetic resonance parameters were determined and correlated to the amount of EAT in 158 patients with CAD and 40 healthy subjects. Patients with CAD and left ventricular function (LVEF) ≥50% revealed significantly elevated EAT (36±11g/m⊃2;) compared to healthy controls (31±8g/m⊃2;) and to patients with LVEF <50% (26±8.0g/m⊃2;). In the whole study population, only LVEF (P=0.003), body mass index (BMI) (P=0.004) and left ventricular end diastolic diameter (LV-EDD) (P=0.004) remained significantly associated with EAT after multivariate analysis. Subgroup analysis in patients with CAD and LVEF ≥50% showed that BMI (P=0.03) was the only correlate of EAT. However, in patients with CAD and LVEF <50%, indexed LV end diastolic mass (LV-EDMI) (P=0.003) and the extent of late gadolinium enhancement (LGE %) (P=0.03) remained significantly correlated with EAT in multivariate analysis. Conclusions: The amount and the determinants of EAT differ according to the LVEF in patients with CAD. Thus, different amounts of EAT reflect different stages of CAD underlining the complex interaction of EAT in the pathogenesis and progression of ischemic cardiomyopathy.  (Circ J 2012; 76: 2426–2434)

• 2012-09-25

著者

• Borggrefe Martin

  Medical Department University Hospital Mannheim

• Suselbeck Tim

  Medical Department University Hospital Mannheim

• Haghi Dariusch

  Medical Department University Hospital Mannheim

• Borggrefe Martin

  Department Of Medicine University Medical Centre Mannheim Medical Faculty Mannheim University Of Heidelberg

• Haghi Dariusch

  Department Of Medicine University Medical Centre Mannheim Medical Faculty Mannheim University Of Heidelberg

• Papavassiliu Theano

  Department Of Medicine University Medical Centre Mannheim Medical Faculty Mannheim University Of Heidelberg

• DOESCH Christina

  Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg

• SUSELBECK Tim

  Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg

• SCHOENBERG Stefan

  Department of Clinical Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg

• Suselbeck Tim

  Department Of Medicine University Medical Centre Mannheim Medical Faculty Mannheim University Of Heidelberg

• Doesch Christina

  Department Of Medicine University Medical Centre Mannheim Medical Faculty Mannheim University Of Heidelberg

• Schoenberg Stefan

  Department Of Clinical Radiology And Nuclear Medicine University Medical Centre Mannheim Medical Faculty Mannheim University Of Heidelberg

関連論文

• Coronary Artery Disease in Takotsubo Cardiomyopathy
• Guidelines for Diagnosis of Takotsubo(Ampulla) Cardiomyopathy(Letter to the Editor)
• Cardiac Sudden Death & Ion Channel Disease(Cardiac Sudden Death & Ion Channel Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Impact of Functional, Morphological and Clinical Parameters on Epicardial Adipose Tissue in Patients With Coronary Artery Disease

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