Clinical and Microbiological Assessment of Trachoma in the Kolofata Health District, Far North Region, Cameroon

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概要

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• Background and aims: Trachoma is a sight-threatening process triggered by the infection of the conjunctiva with Chlamydiae. Blindness associated with trachoma was reported in Sahelian areas of Cameroon. However, data on the prevalence of this neglected infection in the Far North Region are not available. The aim of this study was a) to assess clinical trachoma and b) to detect Chlamydia in the conjunctiva of trachomatous populations living in the Far North Regions of Cameroon.Methods: A total of 2,423 randomly selected children (1–10 years) and 1,590 women over 14 from randomly selected villages from the Kolofata Health District (115,000 inhabitants) were included in a cross-sectional study in February 2009. Trained staff examined and obtained conjunctival swabs from trachomatous subjects. DNA was extracted and amplified to detect Chlamydia DNA by real-time PCR. The quality of sampling was assessed by quantifying the number of epithelial cells.Results: Children (2,397 or 98.9% of the predicted number) and women (1,543; 97.0%) were examined. The prevalence of follicular trachoma (TF) in children was 21% (95% CI 17.8–24.5) and of intense inflammatory trachoma (TI) 5.2% (95% CI 3.6–7.3). Among the women, trichiasis (TT) was observed in 3.4% (95% CI 2.4–4.7), corneal opacities (CO) in 1.4% (95% CI 0.8–2.3) and trachoma-related blindness in 0.9% (95% CI 0.4–1.8). Conditions related to income, illiteracy, latrines, water supply and animals wandering close to dwellings were similar in all the villages. PCR was positive in 35% of children with active trachoma and in 6% of adult females presenting TT and/or related corneal opacities.Conclusion: The prevalence of trachoma and the severe trachoma sequelae found during this survey underline the urgent need to implement efficient blindness prevention interventions to improve the visual future of the people in the Sahelian region.

• 2012-03-01

著者

• Goldschmidt Pablo

  Laboratoire Du C.h.n.o.

• Einterz Ellen

  Hopital Du District De Kolofata

• Ismaila Moustafa

  Ophtalmo Sans Frontieres Hopital De Mayo-oulo

• Bensaid Philippe

  Ophtalmo Sans Frontieres

• Huguet Pierre

  World Health Organization Prevention Of Blindness And Deafness

• Chaumeil Christine

  Centre Hospitaller National D'ophtalmologie Des Quinze-vingts

• BENALLAOUA Djida

  Laboratoire du Centre National d'Ophtalmologie des Quinze-Vingts

• AMZA Abdou

  Faculte des Sciences de la Sante

• EINTERZ Ellen

  Kolofata Health District Hospital

• POISSON Francois

  Service DIM Centre National d'Ophtalmologie des Quinze Vingts

• BILINKAI Aminou

  Ophtalmo sans Frontieres, Hopital de Koussery

• BELLA Lucienne

  Ministry of Public Health

• CHAUMEIL Christine

  Laboratoire du Centre National d'Ophtalmologie des Quinze-Vingts

• Bilinkai Aminou

  Ophtalmo Sans Frontieres Hopital De Koussery

• Benallaoua Djida

  Laboratoire Du Centre National D'ophtalmologie Des Quinze-vingts

• Poisson Francois

  Service Dim Centre National D'ophtalmologie Des Quinze Vingts

関連論文

• Reducing HIV Mortality : A New Paradox for Practitioners Working in Countries with Socialized Health-care Systems
• Clinical and Microbiological Assessment of Trachoma in the Kolofata Health District, Far North Region, Cameroon
• Contributions to the Improvement of Living Conditions among Neglected Populations with Trachoma

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