CADM1/TSLC1 is a Novel Cell Surface Marker for Adult T-cell Leukemia/Lymphoma

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概要

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• <I>CADM1/TSLC1 (Cell adhesion molecule 1/Tumor suppressor in lung cancer 1)</I> is a cell adhesion molecule that was originally identified as a tumor suppressor in lung cancer. <I>CADM1/TSLC1</I> expression is reduced in a variety of cancers via promoter methylation, and this reduction is associated with poor prognosis and enhanced metastatic potential. In contrast, we observed that <I>CADM1/TSLC1</I> is highly and ectopically expressed in all primary adult T-cell leukemia/lymphoma (ATLL) cells and in most human T-cell leukemia virus type (HTLV)-1-infected T-cell and ATLL cell lines. No expression, however, was detected in CD4<SUP>+</SUP> T cells or in several other non-HTLV-1-infected leukemia cells. Moreover, we identified that high CADM1/TSLC1 expression plays an important role in enhanced cell-cell adhesion to the vascular endothelium, tumor growth and the ability of ATLL cells to infiltrate organs. We developed various antibodies as diagnostic tools to identify CADM1<SUP>+</SUP> ATLL cells. Using flow cytometry, we determined that CADM1/TSLC1 is present on the surface of ATLL cells. The percentage of CD4<SUP>+</SUP>CADM1<SUP>+</SUP> cells in the peripheral blood of HTLV-1 carriers and ATLL patients was highly correlated with the DNA copy number of HTLV-1 in lymphocytes. In particular, we identified the soluble form of CADM1/TSLC1 in the peripheral blood of HTLV-1 carriers and ATLL patients. Therefore, measurements of soluble CADM1/TSLC1 serum levels and the detection of CD4<SUP>+</SUP>CADM1<SUP>+</SUP> cells in the blood, when combined with standard diagnostic methods, would be useful for identifying and monitoring disease progression in HTLV-1 carriers. Such tests would provide increased accuracy and may aid in early diagnosis and in determining the effects of ATLL treatments. [<I>J Clin Exp Hematopathol 52(1) : 17-22, 2012</I>]

• 2012-05-01

著者

• Morishita Kazuhiro

  Division Of Tumor And Cellular Biochemistry Department Of Medical Sciences Faculty Of Medicine Unive

• Nakahata Shingo

  Division Of Tumor And Cellular Biochemistry Department Of Medical Sciences Faculty Of Medicine University Of Miyazaki

• MORISHITA Kazuhiro

  Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki

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• CADM1/TSLC1 is a Novel Cell Surface Marker for Adult T-cell Leukemia/Lymphoma

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