High-Sensitivity C-Reactive Protein and Cancer

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概要

• 論文の詳細を見る

• Background: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer is less consistent than that between hs-CRP and cardiovascular diseases. This study explored the association between hs-CRP and cancer, using a large database of Korean health examination records.Methods: A total of 80 781 Koreans who visited the health promotion center of a general hospital were included. There were 729 cases of cancer of any primary site during a 3-year period. Subjects with a known cancer or a condition capable of affecting hs-CRP were excluded.Results: Serum hs-CRP was significantly higher in cancer cases (2.9 mg/L) than in non-cases (1.4 mg/L; P < 0.0001). With the lowest hs-CRP category (<1 mg/L) as reference, the crude odds ratios (ORs) for cancer were 1.36 (95% confidence interval [CI] = 1.16–1.62) for the second highest category (1–3 mg/L) and 2.49 (95% CI = 2.02–3.07) for the highest category (>3 mg/L), and the adjusted ORs for cancer were 1.16 (95% CI = 0.95–1.42) for the second highest category and 1.94 (95% CI = 1.51–2.51) for the highest category. After excluding cancer cases detected within 1 year after the check-up, the associations remained, although the reduced number of cancer cases (n = 88) attenuated the significance of the associations.Conclusions: Serum hs-CRP was positively associated with the risk of cancer, although causality cannot be inferred in this cross-sectional study. The results support the hypothesis that chronic inflammation plays a role in cancer.

• 日本疫学会の論文
• 2011-05-01

著者

• Sung Joohon

  Department Of Epidemiology And Institute Of Health And Environment School Of Public Health Seoul Nat

• Sung Joohon

  Department Of Epidemiology School Of Public Health And Institute Of Health And Environment Seoul National University

• Choe Jae-won

  Health Promotion Center Asan Medical Center University Of Ulsan College Of Medicine

• Kim Hong-kyu

  Health Promotion Center Asan Medical Center University Of Ulsan College Of Medicine

• LEE Seounghee

  Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine

• Lee Seounghee

  Health Promotion Center Asan Medical Center University Of Ulsan College Of Medicine

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• High-Density Lipoprotein Cholesterol, Obesity, and Mammographic Density in Korean Women : The Healthy Twin Study
• Validity of Self-Reported Height and Weight in a Korean Population
• High-Sensitivity C-Reactive Protein and Cancer

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