Structure of the CENP-A nucleosome and its implications for centromeric chromatin architecture
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概要
- 論文の詳細を見る
Centromeres are dictated by the epigenetic inheritance of the centromeric nucleosome containing the centromere-specific histone H3 variant, CENP-A. The structure of the CENP-A nucleosome has been considered to be the fundamental architecture of the centromeric chromatin. Controversy exists in the literature regarding the CENP-A nucleosome structures, with octasome, hemisome, compact octasome, hexasome, and tetrasome models being reported. Some of these CENP-A nucleosome models may correspond to transient intermediates for the assembly of the mature CENP-A nucleosome; however, their significances are still unclear. Therefore, the structure of the mature CENP-A nucleosome has been eagerly awaited. We reconstituted the human CENP-A nucleosome with its cognate centromeric DNA fragment, and determined its crystal structure. In this review, we describe the structure and the physical properties of the CENP-A nucleosome, and discuss their implications for centromeric chromatin architecture.
- 日本遺伝学会の論文
- 2011-12-25
著者
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Kurumizaka Hitoshi
Laboratory Of Cellular & Molecular Biology The Institute Of Physical And Chemical Research (rike
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Tachiwana Hiroaki
Laboratory Of Structural Biology Graduate School Of Advanced Science And Engineering Waseda University
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Kurumizaka Hitoshi
Laboratory Of Structural Biology Graduate School Of Advanced Science And Engineering Waseda University
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