Cerebroprotective Effect of Piracetam in Patients Undergoing Open Heart Surgery
スポンサーリンク
概要
- 論文の詳細を見る
Objectives: Reduction of cognitive function is a possible side effect after the use of cardiopulmonary bypass (CPB) during cardiac surgery. Since it has been proven that piracetam is cerebroprotective in patients undergoing coronary bypass surgery, we investigated the effects of piracetam on the cognitive performance of patients undergoing open heart surgery.Methods: Patients scheduled for elective open heart surgery were randomized to the piracetam or placebo group in a double-blind study. Patients received 12 g of piracetam or placebo at the beginning of the operation. Six neuropsychological subtests from the Syndrom Kurz Test and the Alzheimer’s Disease Assessment Scale were performed preoperatively and on day 3, postoperatively. To assess the overall cognitive function and the degree of cognitive decline across all tests after the surgery, we combined the six test-scores by principal component analysis.Results: A total of 88 patients with a mean age of 67 years were enrolled into the study. The mean duration of CPB was 110 minutes. Preoperative clinical parameters and overall cognitive functions were not significantly different between the groups. The postoperative combined score of the neuropsychological tests showed deterioration of cognitive function in both groups (piracetam: preoperative 0.19 ± 0.97 vs. postoperative -0.97 ± 1.38, p <0.0005 and placebo: preoperative -0.14 ± 0.98 vs. postoperative -1.35 ± 1.23, p <0.0005). Patients taking piracetam did not perform better than those taking placebo, and both groups had the same decline of overall cognitive function (p = 0.955). Conclusion: Piracetam had no cerebroprotective effect in patients undergoing open heart surgery. Unlike the patients who underwent coronary surgery, piracetam did not reduce the early postoperative decline of neuropsychological abilities in heart valve patients.
- Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文
- 2011-04-01
著者
-
Dohmen Pascal
Department Of Cardiovascular Surgery Charite Hospital Medical University Berlin
-
Konertz Wolfgang
Department Of Cardiovascular Surgery Charite Hospital Medical University Berlin
-
Claus Benjamin
Department Of Cardiovascular Surgery Charite-university Medicine Berlin Campus Charite Mitte
-
Neumann Konrad
Department Of Biometry Charite Hospital Medical University
-
HOLINSKI Sebastian
Department of Cardiovascular Surgery, Charite Hospital, Medical University
-
ALAARAJ Nour
Department of Cardiovascular Surgery, Charite Hospital, Medical University
-
UEBELHACK Ralf
Department of Psychiatry, Charite Hospital, Medical University
-
Uebelhack Ralf
Department Of Psychiatry Charite Hospital Medical University
-
Uebelhack Ralf
Department Of Psychiatry And Psychotherapy Charite-universitatsmedizin Berlin Campus Charite Mitte (
-
Holinski Sebastian
Department Of Cardiovascular Surgery Charite Hospital Medical University
-
Claus Benjamin
Department Of Cardiovascular Surgery Charite Hospital Medical University
-
Alaaraj Nour
Department Of Cardiovascular Surgery Charite Hospital Medical University
-
Konertz Wolfgang
Department Of Cardiovascular Surgery Charite Hospital Medical University
-
Dohmen Pascal
Department Of Cardiovascular Surgery Charite Hospital Medical University
関連論文
- Tissue engineering of a pulmonary auto-xenograft heart valve
- Tissue-Engineered Heart Valve Scaffolds
- Shear Bond Strengths of Different Substrates Bonded to Lithium Disilicate Ceramics
- Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome : effect of gender
- Development and Evaluation of a Perfusion Decellularization Porcine Heart Model : Generation of 3-Dimensional Myocardial Neoscaffolds
- Encouraging Experience with Intracardiac Transplantation of Unselected Autologous Bone Marrow Cells Concomitant with Coronary Artery Bypass Surgery after Myocardial Infarction
- Cerebroprotective Effect of Piracetam in Patients Undergoing Open Heart Surgery
- Transfemoral Versus Conventional Aortic Valve Implantation— Early Postoperative Cognitive Outcome —
- Effect of Different Pump Heads for CPB on Early Cognitive Outcome after Coronary Artery Bypass Surgery
- Cardiac Effects of Experimental Intravenous Bone Marrow Cell Transplantation after Myocardial Infarction
- Cerebroprotective Effect of Preoperative Dual Antiplatelet Therapy in Patients Undergoing Coronary Bypass Surgery